Title : Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis.

Pub. Date : 1999 Feb 23

PMID : 10029520






3 Functional Relationships(s)
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1 Decreased apoptosis by JNK1/2 depletion prevented p53 accumulation after the addition of GSNO, which positions JNK1/2 upstream of the p53 response at low agonist concentrations. S-Nitrosoglutathione tumor protein p53 Homo sapiens
2 Decreased apoptosis by JNK1/2 depletion prevented p53 accumulation after the addition of GSNO, which positions JNK1/2 upstream of the p53 response at low agonist concentrations. S-Nitrosoglutathione tumor protein p53 Homo sapiens
3 However, with higher GSNO concentrations apoptotic transducing pathways, including p53 accumulation, were JNK1/2 unrelated. S-Nitrosoglutathione tumor protein p53 Homo sapiens