Pub. Date : 1999 Jan 29
PMID : 10025946
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin-like growth factors I and II are unable to form and maintain their native disulfides under in vivo redox conditions. | Disulfides | insulin like growth factor 1 | Homo sapiens |
| 2 | Insulin-like growth factor (IGF) I does not quantitatively form its three native disulfide bonds in the presence of 10 mM reduced and 1 mM oxidized glutathione in vitro [Hober, S. et al. | Disulfides | insulin like growth factor 1 | Homo sapiens |
| 3 | The results indicate that the previously described thermodynamic disulfide exchange folding problem of IGF-I in vitro is also present in vivo. | Disulfides | insulin like growth factor 1 | Homo sapiens |
| 4 | Speculatively, we suggest that the thermodynamic disulfide exchange properties of IGF-I and II are biologically significant for inactivation of the unbound growth factors by disulfide exchange reactions to generate variants destined for rapid clearance. | Disulfides | insulin like growth factor 1 | Homo sapiens |
| 5 | Speculatively, we suggest that the thermodynamic disulfide exchange properties of IGF-I and II are biologically significant for inactivation of the unbound growth factors by disulfide exchange reactions to generate variants destined for rapid clearance. | Disulfides | insulin like growth factor 1 | Homo sapiens |