Title : Mutations of oncoprotein 18/stathmin identify tubulin-directed regulatory activities distinct from tubulin association.

Pub. Date : 1999 Mar

PMID : 10022911






3 Functional Relationships(s)
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1 However, the MT-destabilizing activities of the coiled-coil mutants are more severely reduced in transfected leukemia cells than those of the Glu-substituted Op18 derivative, providing evidence for tubulin-directed regulatory activities distinct from tubulin complex formation. Glutamic Acid stathmin 1 Homo sapiens
2 Analysis of Op18-mediated regulation of tubulin GTPase activity and taxol-promoted tubulin polymerization showed that while wild-type and Glu-substituted Op18 derivatives are active, the coiled-coil mutants are essentially inactive. Glutamic Acid stathmin 1 Homo sapiens
3 Analysis of Op18-mediated regulation of tubulin GTPase activity and taxol-promoted tubulin polymerization showed that while wild-type and Glu-substituted Op18 derivatives are active, the coiled-coil mutants are essentially inactive. Glutamic Acid stathmin 1 Homo sapiens