Title : Intrarenal site of action of calcium on renin secretion in dogs.

Pub. Date : 1976 Dec

PMID : 1000779






6 Functional Relationships(s)
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1 Intrarenal site of action of calcium on renin secretion in dogs. Calcium renin Canis lupus familiaris
2 We studied the effects of intrarenal calcium infusion on renin secretion in sodium-depleted dogs in an attempt to elucidate the major site of calcium-induced inhibition of renin release. Calcium renin Canis lupus familiaris
3 We studied the effects of intrarenal calcium infusion on renin secretion in sodium-depleted dogs in an attempt to elucidate the major site of calcium-induced inhibition of renin release. Calcium renin Canis lupus familiaris
4 These data indicate that calcium inhibition of renin secretion did not occur primarily at the renal vascular receptor; decreased renal blood flow is usually associated with increased renin secretion. Calcium renin Canis lupus familiaris
5 The observation that calcium still suppressed renin release in these dogs provides additional evidence that the the major effect of calcium involved nontubular mechanisms. Calcium renin Canis lupus familiaris
6 Thus, it appears likely that calcium acted directly on the juxtaglomerular cells to inhibit renin secretion. Calcium renin Canis lupus familiaris