Fluorouracil

tumor protein p53 ; Homo sapiens







354 Article(s)
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51 29434452 PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients. 2018 Feb 7 2
52 29436749 HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5-FU resistance by a p53-dependent pathway. 2018 Jun 2
53 29702091 Inhibition of MALAT1 sensitizes liver cancer cells to 5-flurouracil by regulating apoptosis through IKKα/NF-κB pathway. 2018 Jun 18 1
54 29738772 Dihydroartemisinin potentiates antitumor activity of 5-fluorouracil against a resistant colorectal cancer cell line. 2018 Jun 27 1
55 29772519 p53 and P-glycoprotein influence chemoresistance in hepatocellular carcinoma. 2018 Jun 1 1
56 29795190 Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity. 2018 May 23 3
57 29980405 Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals. 2018 Aug 2
58 30056083 Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. 2018 Oct 1
59 30059758 Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy. 2018 Oct 7
60 30111797 Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. 2018 Aug 14 1
61 30374014 Expression of Micro-RNA-492 (MiR-492) in Human Cervical Cancer Cell Lines is Upregulated by Transfection with Wild-Type P53, Irradiation, and 5-Fluorouracil Treatment In Vitro. 2018 Oct 30 1
62 30539860 Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells. 2018 Dec 2
63 30613833 Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations. 2018 3
64 27637603 The Presence of Serum p53 Antibody Predicts the Pathological Tumor Response to Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and Fluorouracil (DCF) in Esophageal Squamous Cell Carcinoma. 2017 Feb 1
65 28000054 5-Flurouracil disrupts nuclear export and nuclear pore permeability in a calcium dependent manner. 2017 Mar 1
66 28028695 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells. 2017 Feb 4
67 28178647 Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers. 2017 Mar 14 3
68 28284059 Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. 2017 Apr 1
69 28296564 AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells. 2017 1
70 28352348 Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis. 2017 Feb 2
71 28416637 A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response. 2017 Jul 1 2
72 28529594 An active molecule from Pulsatilla chinensis, Pulsatilla saponin A, induces apoptosis and inhibits tumor growth of human colon cancer cells without or with 5-FU. 2017 May 1
73 28656647 Epigenetic silencing of ASPP1 confers 5-FU resistance in clear cell renal cell carcinoma by preventing p53 activation. 2017 Oct 1 1
74 28816773 Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. 2017 Sep 1
75 28851987 P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting. 2017 Aug 29 6
76 28928082 miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin. 2017 Nov 15 5
77 29020632 Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. 2017 Oct 10 1
78 29061672 miR-6883 Family miRNAs Target CDK4/6 to Induce G1 Phase Cell-Cycle Arrest in Colon Cancer Cells. 2017 Dec 15 1
79 25961931 Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. 2016 Feb 25 1
80 26691280 Apoptotic activity of 5-fluorouracil in breast cancer cells transformed by low doses of ionizing α-particle radiation. 2016 Feb 1
81 26774139 Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. 2016 3
82 26840457 Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein. 2016 Feb 23 2
83 26892272 Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells. 2016 May 1
84 27009858 Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress. 2016 May 3 1
85 27044842 The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest. 2016 Apr 2
86 27129209 E2 Ubiquitin-conjugating Enzyme, UBE2C Gene, Is Reciprocally Regulated by Wild-type and Gain-of-Function Mutant p53. 2016 Jul 1 1
87 27144434 MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. 2016 Jun 7 1
88 27527606 Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs. 2016 Aug 16 6
89 27534737 Correction: 5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. 2016 May 10 1
90 27591972 Role of 3' repressor sequences of p53 in anti-cancer drug sensitivity of human lung tumor cells. 2016 Dec 15 2
91 27621580 Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo. 2016 Aug 28 19
92 27777774 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers. 2016 2
93 27835895 Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles. 2016 Nov 29 1
94 27924828 rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment. 2016 Dec 7 2
95 28053293 Correction: 5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. 2016 Nov 1 1
96 28105142 Antitumor effects of recombinant human adenovirus-p53 against human cutaneous squamous cell carcinoma in mice. 2016 Dec 1
97 25310623 5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells. 2015 Jan 3
98 25348361 DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-κB pathway. 2015 Jan 1
99 25502560 Indirect modulation of sensitivity to 5-fluorouracil by microRNA-96 in human colorectal cancer cells. 2015 Feb 1
100 25616665 MicroRNA-520g confers drug resistance by regulating p21 expression in colorectal cancer. 2015 Mar 6 1