trichostatin A

⇄

tumor protein p53 ; Homo sapiens







91 Article(s)
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51 17230511 The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. 2007 Apr 15 1
52 17344317 Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53. 2007 2
53 17669439 Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells. 2007 Dec 1 1
54 21162257 [Protection mechanisms of ATP-sensitive K channels on hippocampal CA1 neurons during chronic severe hypoxia]. 2007 Aug 2
55 16354677 Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. 2006 Jan 4
56 16426753 Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. 2006 May 1 4
57 16467109 Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. 2006 Feb 1 3
58 16474844 Tumor suppressor p53 regulates heparanase gene expression. 2006 Jun 29 1
59 16513842 Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. 2006 Feb 1
60 16847267 MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. 2006 Jul 25 1
61 16865256 Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. 2006 Sep 2
62 15674334 Tumor suppressor p53 represses transcription of RECQ4 helicase. 2005 Mar 3 2
63 15674351 p53 in human embryonal carcinoma: identification of a transferable, transcriptional repression domain in the N-terminal region of p53. 2005 Feb 24 2
64 15746940 Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells. 2005 May 1
65 15827334 Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. 2005 Apr 1
66 15878336 Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). 2005 May 15 1
67 15892716 Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis. 2005 Jun 3
68 15967108 SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. 2005 Apr 2
69 16103091 Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. 2005 Aug 15 1
70 16177181 Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. 2005 1
71 15179185 Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. 2004 Jun 1
72 12556448 Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). 2003 Apr 4 3
73 12716906 The role of p53 deacetylation in p21Waf1 regulation by laminar flow. 2003 Jul 4 4
74 12876282 Transcriptional regulation of mitotic checkpoint gene MAD1 by p53. 2003 Sep 26 1
75 12954772 Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. 2003 Sep 15 1
76 14502645 Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells. 2003 Oct 3
77 14583461 Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. 2003 Oct 15 2
78 14586402 p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. 2003 Oct 30 2
79 14612526 Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. 2003 Nov 1 1
80 14695212 Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. 2003 Dec 15 1
81 21432092 Histone deacetylase inhibitors -Promising agents for 'gene-regulating chemoprevention' and 'molecular-targeting prevention' of cancer-. 2003 Nov 4
82 11791186 Expression of prostate specific antigen (PSA) is negatively regulated by p53. 2002 Jan 3 1
83 11818510 Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. 2002 Feb 2
84 12200149 Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. 2002 Aug 30 2
85 12508652 Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. 2002 Oct 2
86 11283670 Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. 2001 Apr 2
87 11313951 Negative regulation of bcl-2 expression by p53 in hematopoietic cells. 2001 Jan 11 1
88 11093826 Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. 2000 Dec 15 1
89 10521394 Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. 1999 Oct 1 2
90 10667218 Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. 1999 1
91 9405248 Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. 1997 Dec 8 1