IC 831423

serpin family C member 1 ; Homo sapiens







42 Article(s)
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1 29561141 Cooperative Interactions of Three Hotspot Heparin Binding Residues Are Critical for Allosteric Activation of Antithrombin by Heparin. 2018 Apr 17 1
2 25325940 Production of size-defined heparosan, heparan sulfate, and heparin oligosaccharides by enzymatic depolymerization. 2015 1
3 25325941 Chemical modification of heparin and heparosan. 2015 1
4 26340667 Solution Structure of Heparin Pentasaccharide: NMR and DFT Analysis. 2015 Sep 24 2
5 24616065 Affinity capillary electrophoresis for the determination of binding affinities for low molecular weight heparins and antithrombin-III. 2014 May 1
6 24068708 The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D. 2013 Nov 22 2
7 19497853 Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function. 2009 Jul 31 1
8 19661062 The signature 3-O-sulfo group of the anticoagulant heparin sequence is critical for heparin binding to antithrombin but is not required for allosteric activation. 2009 Oct 2 3
9 19818773 Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement. 2009 Nov 3 1
10 17875649 Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin. 2007 Nov 16 1
11 16085538 Fondaparinux: a potential new therapy for HIT. 2005 Aug 1
12 14730971 Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change. 2004 Jan 27 1
13 12846563 Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites. 2003 Jul 15 2
14 12873131 Crystal structure of antithrombin in a heparin-bound intermediate state. 2003 Jul 29 1
15 12939144 Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability. 2003 Sep 2 1
16 11854268 Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide. 2002 May 3 1
17 12353073 Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity. 2002 Sep 2
18 12532174 Fondaparinux sodium. 2002 Mar 2
19 11278930 Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin. 2001 May 4 1
20 11567021 Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding. 2001 Nov 23 1
21 11583572 Conformation of heparin pentasaccharide bound to antithrombin III. 2001 Oct 15 1
22 10660568 Serine 380 (P14) --> glutamate mutation activates antithrombin as an inhibitor of factor Xa. 2000 Feb 11 1
23 10764763 Role of arginine 129 in heparin binding and activation of antithrombin. 2000 Jun 23 1
24 10966821 Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin. 2000 Sep 1 1
25 10984531 Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site. 2000 Sep 12 2
26 10433728 The role of Arg46 and Arg47 of antithrombin in heparin binding. 1999 Aug 3 1
27 10497166 Importance of the P2 glycine of antithrombin in target proteinase specificity, heparin activation, and the efficiency of proteinase trapping as revealed by a P2 Gly --> Pro mutation. 1999 Oct 1 3
28 9516447 Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin. 1998 Mar 27 1
29 9541411 The N-terminal segment of antithrombin acts as a steric gate for the binding of heparin. 1998 Mar 1
30 9763552 Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation. 1998 Oct 15 1
31 9784873 Synthesis of a 3-deoxy-L-iduronic acid containing heparin pentasaccharide to probe the conformation of the antithrombin III binding sequence. 1998 Aug 1
32 9065421 Lysine residue 114 in human antithrombin III is required for heparin pentasaccharide-mediated activation. 1997 Mar 21 1
33 9184148 The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change. 1997 Jun 3 2
34 9242619 Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity. 1997 Aug 8 4
35 7757423 Feasible synthesis and biological properties of six 'non-glycosamino' glycan analogues of the antithrombin III binding heparin pentasaccharide. 1994 Nov 1
36 7947827 Lysine-heparin interactions in antithrombin. Properties of K125M and K290M,K294M,K297M variants. 1994 Nov 29 1
37 8167338 Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexes. 1994 May 1 1
38 8218292 Parallel mechanisms of high molecular weight kininogen action as a cofactor in kallikrein inactivation and prekallikrein activation reactions. 1993 Nov 16 2
39 1618758 Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. 1992 Jun 25 1
40 2713873 Examination, by 1H-n.m.r. spectroscopy, of the binding of a synthetic, high-affinity heparin pentasaccharide to human antithrombin III. 1989 Jan 15 1
41 2902851 Effect of oversulphated chondroitin and dermatan sulphate upon thrombin and factor Xa inactivation by antithrombin III or heparin cofactor II. 1988 Sep 1 2
42 3767984 Structure activity relationship in heparin: stimulation of non-vascular cells by a synthetic heparin pentasaccharide in cooperation with human acidic fibroblast growth factors. 1986 Sep 14 1