Folic Acid

gamma-glutamyl hydrolase ; Homo sapiens







38 Article(s)
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1 35040120 A γ-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells. 2022 Feb 4
2 35082830 Elevated Expression of Gamma-Glutamyl Hydrolase Is Associated With Poor Prognosis and Altered Immune Signature in Uterine Corpus Endometrial Carcinoma. 2021 2
3 31754833 High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1. 2020 Jan 2
4 32238907 CpG-SNP site methylation regulates allele-specific expression of MTHFD1 gene in type 2 diabetes. 2020 Aug 1
5 32256983 Enzymes involved in folate metabolism and its implication for cancer treatment. 2020 Apr 5
6 30409571 Quantification of polyglutamyl 5-methyltetrahydrofolate, monoglutamyl folate vitamers, and total folates in different berries and berry juice by UHPLC-MS/MS. 2019 Mar 15 5
7 31223065 Folate pathway genes linked to mitochondrial biogenesis and respiration are associated with outcome of patients with stage III colorectal cancer. 2019 Jun 1
8 31739835 The role of transcription factor Sp1 in the regulation of gamma-glutamyl hydrolase gene expression by the rs3758149 polymorphism in CEM/C1 cells. 2019 Nov 1 2
9 29955722 Addition of Exogenous γ-Glutamyl Hydrolase Eliminates the Need for Lengthy Incubation of Whole-Blood Lysate for Quantitation of Folate Vitamers by High-Performance Liquid Chromatography-Tandem Mass Spectrometry. 2018 Jan 2
10 28146062 High-Level γ-Glutamyl-Hydrolase (GGH) Expression is Linked to Poor Prognosis in ERG Negative Prostate Cancer. 2017 Jan 29 2
11 28278270 Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia. 2017 2
12 25502219 γ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. 2015 Jan 5
13 26198726 Serum protein gamma-glutamyl hydrolase, Ig gamma-3 chain C region, and haptoglobin are associated with the syndromes of pulmonary tuberculosis in traditional Chinese medicine. 2015 Jul 22 1
14 24447348 Folic acid pathway single nucleotide polymorphisms associated with methotrexate significant adverse events in United States veterans with rheumatoid arthritis. 2014 May-Jun 1
15 25364408 Thymidine phosphorylase mRNA expression may be a predictor of response to post-operative adjuvant chemotherapy with S-1 in patients with stage III colorectal cancer. 2014 Dec 1
16 24045662 γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate. 2013 Oct 15 6
17 22018726 Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study. 2012 Jan 3
18 22568793 Genetic polymorphism of γ-glutamyl hydrolase in Chinese acute leukemia children and identification of a novel double nonsynonymous mutation. 2012 May 2
19 19636555 Molecular determinants of folate levels after leucovorin administration in colorectal cancer. 2010 Mar 1
20 19764999 Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels. 2009 Dec 1
21 18035049 Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity. 2008 Jan 25 1
22 18171026 Gamma-glutamyl hydrolase: kinetic characterization of isopeptide hydrolysis using fluorogenic substrates. 2008 Jan 29 1
23 18414409 Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype. 2008 May 6 2
24 18804701 Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target. 2008 3
25 18842806 Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. 2008 Oct 2
26 17439143 Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. 2007 May 16 2
27 16826517 Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. 2006 Aug 2
28 16859665 Gamma-glutamyl hydrolase and drug resistance. 2006 Dec 5
29 16945597 Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. 2006 Sep 1
30 12909365 Characterization of the human gamma-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines. 2003 Jul 17 1
31 14597182 Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. 2003 Nov 13 2
32 14660354 Controlled modulation of folate polyglutamyl tail length by metabolic engineering of Lactococcus lactis. 2003 Dec 1
33 14676127 Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. 2003 Dec 1 2
34 11389096 Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance. 2001 Jun 1 1
35 10739875 Glutamyl hydrolase. pharmacological role and enzymatic characterization. 2000 Mar 2
36 10527932 Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase. 1999 Nov 1 2
37 10570974 Structural organization of the human gamma-glutamyl hydrolase gene. 1999 Oct 1 2
38 9647673 Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate. 1998 Jul 1 2