Dinoprostone

AKT serine/threonine kinase 1 ; Homo sapiens







78 Article(s)
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1 35121582 The COX-2-PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas. 2022 May 3 2
2 35242277 Sphingosine 1-Phosphate-Upregulated COX-2/PGE2 System Contributes to Human Cardiac Fibroblast Apoptosis: Involvement of MMP-9-Dependent Transactivation of EGFR Cascade. 2022 2
3 32843585 Thymoquinone Suppresses Migration of Human Renal Carcinoma Caki-1 Cells through Inhibition of the PGE2-Mediated Activation of the EP2 Receptor Pathway. 2021 Jan 1 1
4 34216690 Intracellular AGR2 transduces PGE2 stimuli to promote epithelial-mesenchymal transition and metastasis of colorectal cancer. 2021 Oct 10 2
5 34496236 Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche. 2021 Sep 7 2
6 34619972 Tumor-associated macrophages increase COX-2 expression promoting endocrine resistance in breast cancer via the PI3K/Akt/mTOR pathway. 2021 Sep 2
7 34945337 Low Intensity Pulsed Ultrasound for Bone Tissue Engineering. 2021 Nov 30 1
8 31734182 Prostaglandin E2 Induces miR675-5p to Promote Colorectal Tumor Metastasis via Modulation of p53 Expression. 2020 Mar 1
9 31837749 PGE2 ameliorated viral myocarditis development and promoted IL-10-producing regulatory B cell expansion via MAPKs/AKT-AP1 axis or AhR signaling. 2020 Jan 2
10 32904445 Inhibition of PI3K-AKT Signaling Blocks PGE2-Induced COX-2 Expression in Lung Adenocarcinoma. 2020 5
11 33038299 Prostaglandin D2 strengthens human endothelial barrier by activation of E-type receptor 4. 2020 Dec 1
12 30367494 PROSTAGLANDIN E2 stimulates cancer-related phenotypes in prostate cancer PC3 cells through cyclooxygenase-2. 2019 May 2
13 30660713 Cyclooxygenase-2 regulates HPS patient serum induced-directional collective HPMVEC migration via PKC/Rac signaling pathway. 2019 Apr 15 1
14 30758990 Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling. 2019 May 1 2
15 30798160 Magnolol prevents ossified tendinopathy by inhibiting PGE2-induced osteogenic differentiation of TDSCs. 2019 May 2
16 29085960 Transforming growth factor-β1 and phosphatases modulate COX-2 protein expression and TAU phosphorylation in cultured immortalized podocytes. 2018 Feb 1
17 30324106 Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway. 2018 1
18 27506158 PGE2 /EP4 Signaling Controls the Transfer of the Mammary Stem Cell State by Lipid Rafts in Extracellular Vesicles. 2017 Feb 1
19 28407559 Positive feedback effect of PGE2 on cyclooxygenase-2 expression is mediated by inhibition of Akt phosphorylation in human follicular dendritic cell-like cells. 2017 Jul 4
20 28587064 Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. 2017 May 25 1
21 29358963 Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3β/β-Catenin Signaling Pathway. 2017 3
22 27086487 Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC. 2016 May 1
23 27506466 Menopause-induced uterine epithelium atrophy results from arachidonic acid/prostaglandin E2 axis inhibition-mediated autophagic cell death. 2016 Aug 10 2
24 27590200 Apocynin inhibits Toll-like receptor-4-mediated activation of NF-κB by suppressing the Akt and mTOR pathways. 2016 Dec 1
25 27695098 Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis. 2016 1
26 27795708 Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. 2016 1
27 25575814 MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis. 2015 Jan 1 2
28 25849942 Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs. 2015 Mar 20 1
29 25971793 Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-κB pathways. 2015 Sep 1
30 26058972 Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor. 2015 Aug 1
31 26059638 Collagen and prostaglandin E₂ regulate aromatase expression through the PI3K/AKT/IKK and the MAP kinase pathways in adipose stromal cells. 2015 Sep 3
32 26188043 Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. 2015 Jul 17 1
33 26310818 Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1. 2015 Nov 15 1
34 26352871 Upregulation of C-C chemokine receptor type 7 expression by membrane-associated prostaglandin E synthase-1/prostaglandin E2 requires glycogen synthase kinase 3β-mediated signal transduction in colon cancer cells. 2015 Nov 1
35 24441870 TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells. 2014 Mar 15 1
36 24621265 Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ between glial and neuron cells. 2014 Aug 1
37 24626807 Prostaglandin E₂ receptor EP2 mediates Snail expression in hepatocellular carcinoma cells. 2014 May 1
38 24760275 Prostaglandin E2 accelerates invasion by upregulating Snail in hepatocellular carcinoma cells. 2014 Jul 3
39 25229003 Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-κB Pathways in Nasal Polyp-Derived Fibroblasts. 2014 Sep 4
40 25332857 Differential regulation of c-Met signaling pathways for synovial cell function. 2014 1
41 22580611 PGE2 promotes renal carcinoma cell invasion through activated RalA. 2013 Mar 14 1
42 22718198 Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells. 2013 Feb 1
43 23149922 MIG-7 controls COX-2/PGE2-mediated lung cancer metastasis. 2013 Jan 1 1
44 23515290 TGF-β effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway. 2013 May 5
45 22214188 Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia. 2012 Jan 3 2
46 22378492 Cooperation of Epac1/Rap1/Akt and PKA in prostaglandin E(2) -induced proliferation of human umbilical cord blood derived mesenchymal stem cells: involvement of c-Myc and VEGF expression. 2012 Dec 2
47 22983360 Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. 2012 Nov 2
48 22096605 Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. 2011 1
49 19841066 Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. 2010 Jan 2
50 20093341 Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. 2010 Apr 1