2-mercaptopyrazine

thiopurine S-methyltransferase ; Homo sapiens







306 Article(s)
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1 34412101 Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia. 2022 Feb 1 3
2 35118815 Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity. 2022 Apr 1
3 35387339 LC-MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity. 2022 2
4 35468862 A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population. 2022 Apr 25 2
5 32865889 Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism. 2021 Jan 1
6 33470487 Differential effects of mesalazine formulations on thiopurine metabolism through thiopurine S-methyltransferase inhibition. 2021 Aug 2
7 33675810 NUDT15: A bench to bedside success story. 2021 Jun 2
8 33913342 Automation of the Whole-Blood Thiopurine S-Methyltransferase (TPMT) Phenotyping Assay Using the Biomek NXP and Biomek i5 Liquid-Handling Workstations. 2021 Oct 1
9 33958640 Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT. 2021 May 6 4
10 34425754 TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India. 2021 Aug 23 2
11 34563096 Randomised clinical trial: dose optimising strategy by NUDT15 genotyping reduces leucopenia during thiopurine treatment of Crohn's disease. 2021 Nov 1
12 34720526 Biomarkers for gastrointestinal adverse events related to thiopurine therapy. 2021 Oct 14 1
13 31651720 Pharmacogeomic implications of population diversity in Latin America: TPMT and NUDT15 polymorphisms and thiopurine dosing. 2020 Jan 1
14 32124692 Clinical Application of Thiopurine Pharmacogenomics in Pediatrics. 2020 1
15 32453263 Pharmacogenomics of thiopurines: distribution of TPMT and NUDT15 polymorphisms in the Brazilian Amazon. 2020 Oct 1
16 32482022 NUDT15 gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease. 2020 Jul 2
17 32611418 Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT. 2020 Jul 1 4
18 32944042 Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study. 2020 Fall 2
19 32973300 Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier. 2020 Dec 2
20 33081236 Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT. 2020 Oct 16 1
21 33111378 NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India. 2020 Dec 2
22 33162513 [Genetic basis of subsequent malignant neoplasms]. 2020 1
23 30447069 Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update. 2019 May 1
24 30451123 Thiopurine Methyltransferase Genetic Polymorphisms and Activity and Metabolic Products of Azathioprine in Patients with Inflammatory Bowel Disease. 2019 3
25 30452647 Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis. 2019 Jan 10 1
26 30686035 [Frequency of serious adverse events of thiopurine treatment in normal thiopurine S-methyltransferase genotype children with inflammatory bowel disease]. 2019 Feb 1
27 30689858 Systematic Review: Cost-effective Strategies of Optimizing Anti-tumor Necrosis and Immunomodulators in Inflammatory Bowel Disease. 2019 Aug 20 1
28 30698675 Genotype-Guided Thiopurine Dosing Does not Lead to Additional Costs in Patients With Inflammatory Bowel Disease. 2019 Jul 25 2
29 30728528 Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry. 2019 Sep 3
30 30845128 New Zealand Society of Gastroenterology Guidelines on Therapeutic Drug Monitoring in Inflammatory Bowel Disease. 2019 Mar 8 1
31 30901734 Development and validation of a UPLC-UV method for the quantification of thiopurine methyltransferase enzyme activity in human erythrocytes. 2019 Apr 15 1
32 30935835 Development of duplex-crossed allele-specific PCR targeting of TPMT*3B and *3C using crossed allele-specific blockers to eliminate non-specific amplification. 2019 Jun 15 1
33 30945335 Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tango. 2019 Jul 1
34 31005613 Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden. 2019 Jun 5
35 31210708 Predicting (side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics. 2019 Jun 7 2
36 31244663 Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients. 2019 2
37 31342537 Systematic review with meta-analysis: risk factors for thiopurine-induced leukopenia in IBD. 2019 Sep 2
38 31352659 The Evolving Role of Thiopurines in Inflammatory Bowel Disease. 2019 Sep 1
39 31639757 Retrospective Data Analysis of the Influence of Age and Sex on TPMT Activity and Its Phenotype-Genotype Correlation. 2019 Mar 2
40 29192347 Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping. 2018 Feb 1
41 29194039 Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate. 2018 Apr 25 2
42 29210335 Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients. 2018 Jan 2
43 29226409 Editorial: thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype-the perils of ageing. 2018 Jan 1
44 29226420 Editorial: thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype-the perils of ageing. Authors' reply. 2018 Jan 1
45 29425801 Analytical and clinical validation of an LC-MS/MS method to measure thiopurine S-methyltransferase activity by quantifying d3-6-MMP. 2018 Apr 1
46 29436466 Evaluation of prescriber responses to pharmacogenomics clinical decision support for thiopurine S-methyltransferase testing. 2018 Feb 15 2
47 29444714 Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values. 2018 Feb 14 1
48 29470173 Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity. 2018 Mar 28 2
49 29801578 The Pharmacogenetics of Immune-Modulating Therapy. 2018 3
50 30086084 Distribution of Genetic Polymorphisms of Genes Implicated in Thiopurine Drugs Metabolism. 2018 Oct 2