| 1 |
34744007 | Amyloid beta increases ABCA1 and HMGCR protein expression, and cholesterol synthesis and accumulation in mice neurons and astrocytes. | 2022 Jan |
6 |
| 2 |
35104501 | The calcium-free form of atorvastatin inhibits amyloid-β(1-42) aggregation in vitro. | 2022 Mar |
1 |
| 3 |
34219248 | Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β-amyloid peptide accumulation in mice. | 2021 Sep |
1 |
| 4 |
34299071 | Liver Bile Acid Changes in Mouse Models of Alzheimer's Disease. | 2021 Jul 12 |
1 |
| 5 |
34385305 | Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol. | 2021 Aug 17 |
1 |
| 6 |
34488598 | Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer's Disease. | 2021 |
2 |
| 7 |
32706788 | A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease. | 2020 Jul |
2 |
| 8 |
30448407 | Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus. | 2019 Feb |
2 |
| 9 |
30882716 | Treadmill exercise inhibits amyloid-β generation in the hippocampus of APP/PS1 transgenic mice by reducing cholesterol-mediated lipid raft formation. | 2019 May 1 |
3 |
| 10 |
28941799 | Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells. | 2018 Jan |
1 |
| 11 |
29530923 | Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells. | 2018 Jun 1 |
2 |
| 12 |
29862881 | Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion. | 2018 |
1 |
| 13 |
28579886 | D-4F decreases the expression of Aβ protein through up-regulating long non coding RNA sirt1-as in SAMP8 mice. | 2017 May |
2 |
| 14 |
26484906 | Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer's Disease (3xTg-AD). | 2016 |
1 |
| 15 |
26724580 | Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia. | 2016 Mar 1 |
1 |
| 16 |
26200696 | Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes. | 2015 Dec |
1 |
| 17 |
26433932 | APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease. | 2015 Dec 15 |
3 |
| 18 |
24815354 | Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking. | 2014 Jul |
4 |
| 19 |
24854439 | Ginsenoside Rh2 promotes nonamyloidgenic cleavage of amyloid precursor protein via a cholesterol-dependent pathway. | 2014 May 9 |
1 |
| 20 |
23542729 | Liver X receptors: emerging therapeutic targets for Alzheimer's disease. | 2013 Jun |
1 |
| 21 |
23648430 | APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease. | 2013 Sep 1 |
2 |
| 22 |
23707801 | Substitution of membrane cholesterol with β-sitosterol promotes nonamyloidogenic cleavage of endogenous amyloid precursor protein. | 2013 Sep 5 |
2 |
| 23 |
24107941 | Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study. | 2013 Oct 9 |
1 |
| 24 |
22573671 | β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage. | 2012 May 9 |
4 |
| 25 |
22796523 | Cholesterol enhances amyloid β deposition in mouse retina by modulating the activities of Aβ-regulating enzymes in retinal pigment epithelial cells. | 2012 Aug 10 |
6 |
| 26 |
22869680 | Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin. | 2012 Nov 15 |
1 |
| 27 |
21274438 | The pathological roles of ganglioside metabolism in Alzheimer's disease: effects of gangliosides on neurogenesis. | 2011 Jan 9 |
1 |
| 28 |
21483097 | Cholesterol and amyloid-β: evidence for a cross-talk between astrocytes and neuronal cells. | 2011 |
5 |
| 29 |
21876828 | Copper modulation as a therapy for Alzheimer's disease? | 2011 |
1 |
| 30 |
19654569 | Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. | 2010 Jan |
1 |
| 31 |
20155813 | Regulation of cholesterol efflux by amyloid beta secretion. | 2010 Jul |
11 |
| 32 |
20157255 | Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. | 2010 |
2 |
| 33 |
20374280 | beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts. | 2010 Mar |
1 |
| 34 |
20430703 | Post-prandial lipid metabolism, lipid-modulating agents and cerebrovascular integrity: implications for dementia risk. | 2010 Jun |
1 |
| 35 |
20638472 | Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. | 2010 Oct 15 |
3 |
| 36 |
20690163 | Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity. | 2010 Oct |
1 |
| 37 |
20847045 | Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. | 2010 Nov 19 |
1 |
| 38 |
18618086 | Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells. | 2009 Jan |
2 |
| 39 |
19130883 | DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. | 2009 Mar |
1 |
| 40 |
19204288 | Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan. | 2009 Mar 3 |
1 |
| 41 |
19239689 | Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1. | 2009 Feb 24 |
1 |
| 42 |
19458211 | Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. | 2009 May 20 |
1 |
| 43 |
19625658 | Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. | 2009 Nov |
2 |
| 44 |
19784764 | Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease. | 2009 Oct |
6 |
| 45 |
18410513 | High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. | 2008 Jul |
1 |
| 46 |
18855586 | The cholesterol transport inhibitor U18666a regulates amyloid precursor protein metabolism and trafficking in N2aAPP "Swedish" cells. | 2008 Oct |
4 |
| 47 |
17336088 | The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. | 2007 Apr |
3 |
| 48 |
17472586 | Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. | 2007 May |
1 |
| 49 |
17472705 | Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. | 2007 Aug |
3 |
| 50 |
17706358 | Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome. | 2007 Aug 16 |
3 |