Folic Acid

dihydrofolate reductase ; Mus musculus

17 Article(s)
Pub. Year
#Total Relationships
1 35139535 Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification. 2022 May 1 1
2 33126053 Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. 2021 Jan 2
3 30502384 Methotrexate induces astrocyte apoptosis by disrupting folate metabolism in the mouse juvenile central nervous system. 2019 Feb 1
4 26830229 Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr. 2016 Apr 1
5 24558445 Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice. 2014 2
6 22083158 Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. 2012 Jan 1
7 22549734 The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes. 2012 Jul 2
8 22891343 Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections. 2012 Aug 28 2
9 21550412 Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. 2011 Aug 1 2
10 19110071 Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: intervention of folic and folinic acid. 2009 Feb 19 2
11 19660467 Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. 2009 Dec 5
12 8934221 The hematological effects of folate analogs: implications for using the dihydrofolate reductase gene for in vivo selection. 1996 Nov 10 1
13 7728929 Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. I: Synthesis and biological properties of pyrrolo[2,3-d]pyrimidine antifolates containing tetrazole congener of glutamic acid. 1995 Feb 1
14 1533575 Simultaneous changes in various mechanisms that mediate the cell incorporation of folate compounds account for low levels of resistance to methotrexate. 1992 Mar 1
15 2909524 A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. 1989 Jan 5 1
16 3016548 Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. 1986 Jul 17-23 1
17 6189586 Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate reductase by 5-formyltetrahydrofolate in Ehrlich ascites tumor cells in vitro. 1983 Jun 1