Fatty Acids, Nonesterified

free fatty acid receptor 1 ; Homo sapiens







37 Article(s)
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1 34383332 Dispersion and utilization of lipid droplets mediates respiratory syncytial virus-induced airway hyperresponsiveness. 2022 Jan 1
2 35203397 Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook. 2022 Feb 21 2
3 34321316 SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans. 2021 Oct 1
4 34480991 The role of fatty acids in Crohn's disease pathophysiology - An overview. 2021 Dec 1 1
5 31465594 G protein-coupled receptor 40 expression in human melanoma - correlation with tumour thickness, AJCC stage and survival. 2020 Feb 1
6 32026734 Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells. 2020 Apr 2
7 32799609 GPR120 agonists for the treatment of diabetes: a patent review (2014 present). 2020 Oct 1
8 32851580 Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics. 2020 Nov 3
9 29929407 Role of GPR40 in pathogenesis and treatment of Alzheimer's disease and type 2 diabetic dementia. 2019 Apr 2
10 31516639 Obesity-induced asthma: Role of free fatty acid receptors. 2019 Nov 2
11 28727908 Leveraging a Clinical Phase Ib Proof-of-Concept Study for the GPR40 Agonist MK-8666 in Patients With Type 2 Diabetes for Model-Informed Phase II Dose Selection. 2017 Sep 1
12 26974599 Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry. 2016 Apr 5 2
13 27121981 GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway. 2016 Apr 28 1
14 27163640 Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells. 2016 Jun 17 1
15 25131623 Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4. 2015 Jul 1
16 24749055 Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1. 2014 Jun 1
17 25161890 Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans. 2014 Sep 1
18 25274213 [Host energy regulation via SCFAs receptors, as dietary nutrition sensors, by gut microbiota]. 2014 1
19 23599801 Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells. 2013 Apr 1
20 22051148 GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes. 2012 Mar 2
21 22106100 The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets. 2012 Feb 2
22 22560300 GPR119 as a fat sensor. 2012 Jul 1
23 22669289 A multiple-ascending-dose study to evaluate safety, pharmacokinetics, and pharmacodynamics of a novel GPR40 agonist, TAK-875, in subjects with type 2 diabetes. 2012 Jul 4
24 22859723 Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. 2012 Nov 1
25 23060857 Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets. 2012 1
26 21570468 Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. 2011 Aug 2
27 21663979 Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. 2011 Sep 1
28 19346435 Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor. 2009 Jun 1
29 19398560 The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. 2009 Jun 26 2
30 17980148 Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1). 2008 Jan 4 1
31 18855625 GPR40 carboxylic acid receptor family and diabetes: a new drug target. 2008 Oct 1
32 17583366 Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys. 2007 Aug 2
33 17699519 Identification of residues important for agonist recognition and activation in GPR40. 2007 Oct 5 1
34 17987108 Variants in the FFAR1 gene are associated with beta cell function. 2007 Nov 7 1
35 16081037 Role of GPR40 in fatty acid action on the beta cell line INS-1E. 2005 Sep 16 1
36 12629551 Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. 2003 Mar 13 1
37 12684041 Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. 2003 Apr 18 1