NAD

nicotinamide phosphoribosyltransferase ; Homo sapiens







359 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 34260721 Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress. 2022 Feb 1 3
2 35203360 Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise. 2022 Feb 17 2
3 35219878 NAMPT: A critical driver and therapeutic target for cancer. 2022 Apr 6
4 35241643 miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation. 2022 Mar 4 3
5 35251333 Sirtuin 1 participates in intervertebral disc degeneration via the nicotinamide phosphoribosyl transferase/nicotinamide adenine dinucleotide/sirtuin 1 pathway responsible for regulating autophagy of nucleus pulposus cells. 2022 Apr 1
6 35272691 Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties. 2022 Mar 10 4
7 35396381 Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia. 2022 Apr 8 2
8 35402885 Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4. 2022 Apr 15 2
9 35408818 NAD+ Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy. 2022 Mar 22 3
10 35410407 NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress. 2022 Apr 11 6
11 35459935 Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. 2022 Jun 2
12 35488293 Correction: Mesenchymal stromal cells attenuate alveolar type 2 cells senescence through regulating NAMPT‑mediated NAD metabolism. 2022 Apr 29 1
13 35500221 IFNγ Regulates NAD+ Metabolism to Promote the Respiratory Burst in Human Monocytes. 2022 May 2 7
14 35616339 The Clock-NAD+ -Sirtuin connection in nonalcoholic fatty liver disease. 2022 May 26 2
15 35628596 Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model. 2022 May 21 2
16 33038343 Non-canonical roles of NAMPT and PARP in inflammation. 2021 Feb 2
17 33171124 NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion. 2021 Jan 5 2
18 33349973 The nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of prostate tumour spheroids and increases doxorubicin retention without changes in drug transporter and cancer stem cell protein expression. 2021 Mar 2
19 33522796 Tripeptide IRW Upregulates NAMPT Protein Levels in Cells and Obese C57BL/6J Mice. 2021 Feb 10 2
20 33546767 NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells. 2021 Feb 5 4
21 33597293 NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition. 2021 Feb 23 8
22 33606677 Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action. 2021 2
23 33771896 Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments. 2021 Jul 1 3
24 33777213 NAMPT promotes hepatitis B virus replication and liver cancer cell proliferation through the regulation of aerobic glycolysis. 2021 May 2
25 33798699 Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. 2021 Jun 1 5
26 33887438 Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition. 2021 Jul 1 3
27 33912035 Dezocine, An Opioid Analgesic, Exerts Antitumor Effects in Triple-Negative Breast Cancer by Targeting Nicotinamide Phosphoribosyltransferase. 2021 1
28 33918226 Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process. 2021 Apr 2 2
29 33957971 MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway. 2021 May 6 4
30 33976173 A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages. 2021 May 11 1
31 34029951 Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling. 2021 Aug 4
32 34046646 NAD+ oscillation and hypothalamic neuronal functions. 2021 4
33 34068917 Advances in NAD-Lowering Agents for Cancer Treatment. 2021 May 14 2
34 34101492 MiR-613 Promotes Cell Death in Breast Cancer Cells by Downregulation of Nicotinamide Phosphoribosyltransferase and Reduction of NAD. 2021 Jul 6
35 34103421 Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. 2021 Jun 8 1
36 34130091 Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. 2021 Aug 8
37 34200964 Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression. 2021 Jun 10 1
38 34202251 Enhanced NAMPT-Mediated NAD Salvage Pathway Contributes to Psoriasis Pathogenesis by Amplifying Epithelial Auto-Inflammatory Circuits. 2021 Jun 25 6
39 34229568 Structure-based virtual screening, molecular dynamics simulation and in vitro evaluation to identify inhibitors against NAMPT. 2021 Jul 6 2
40 34253597 PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus. 2021 Oct 2
41 34290089 Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. 2021 Jul 3
42 34322899 Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma. 2021 Dec 2
43 34382917 NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. 2021 Sep 1
44 34399423 Dual Roles of Nicotinamide Phosphoribosyltransferase as a Promising Target for Cancer Radiotherapy. 2021 Oct 1 7
45 34509469 The balance between NAD+ biosynthesis and consumption in ageing. 2021 Oct 1
46 34639240 Correction: Feng et al. Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway. Int. J. Mol. Sci. 2020, 21, 4655. 2021 Oct 8 4
47 34748530 NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. 2021 Nov 2
48 34752167 NAMPT-mediated NAD+ biosynthesis suppresses activation of hepatic stellate cells and protects against CCl4-induced liver fibrosis in mice. 2021 Dec 7
49 31059816 Targeting metabolic reprogramming in metastatic melanoma: The key role of nicotinamide phosphoribosyltransferase (NAMPT). 2020 Feb 3
50 31710095 Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men. 2020 Feb 2