Phosphotyrosine

spleen associated tyrosine kinase ; Homo sapiens







27 Article(s)
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1 31216232 Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ. 2019 Aug 1 1
2 26468009 Insights into the allosteric regulation of Syk association with receptor ITAM, a multi-state equilibrium. 2016 Feb 17 4
3 25287889 Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. 2015 Jan 1 1
4 26096845 Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. 2015 Jul 13 1
5 23955592 Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain. 2013 Nov 1
6 22776094 The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL. 2012 Nov 2
7 20013945 Human spleen tyrosine kinase (Syk) recombinant expression systems for high-throughput assays. 2010 Feb 2
8 19421152 Phosphoproteomic analysis of Syk kinase signaling in human cancer cells reveals its role in cell-cell adhesion. 2009 Jun 18 2
9 18689684 Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling. 2008 Aug 19 1
10 17035319 Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity. 2007 Jan 1
11 16410013 Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase. 2006 Mar 10 2
12 15536084 Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. 2005 Jan 14 2
13 16085052 Effector-induced Syk-mediated phosphorylation in human erythrocytes. 2005 Aug 15 1
14 12171941 The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. 2002 Oct 18 2
15 11133830 The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation. 2001 Jan 1
16 11465093 FcgammaRIIA exogenously expressed in HeLa cells activates the mitogen-activated protein kinase cascade by a mechanism dependent on the endogenous expression of the protein tyrosine kinase Syk. 2001 May 2
17 11828442 Peptoid - peptide hybrids that bind Syk SH2 domains involved in signal transduction. 2001 Mar 2 1
18 9880513 Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells. 1999 Jan 15 1
19 9698567 Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. 1998 Aug 21 1
20 9092538 Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif. 1997 Apr 11 1
21 9245716 Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage. 1997 Jul 30 1
22 8663178 Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting. 1996 Jul 12 1
23 7559493 Temporal activation of nontransmembrane protein-tyrosine kinases following mast cell Fc epsilon RI engagement. 1995 Oct 6 1
24 8590001 Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide. 1995 Oct 15 2
25 7522230 Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement. 1994 Sep 23 1
26 7525568 Interactions of Lyn with the antigen receptor during B cell activation. 1994 Nov 11 1
27 8340414 Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling. 1993 Jul 25 1