Dipeptides

C9orf72-SMCR8 complex subunit ; Homo sapiens







119 Article(s)
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1 34170347 Synthetic hydrogel mimics of the nuclear pore complex for the study of nucleocytoplasmic transport defects in C9orf72 ALS/FTD. 2022 Jan 1
2 34534264 Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA. 2022 Apr 18 1
3 34791698 C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation. 2022 Jan 4 1
4 34992216 Publisher Correction: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression. 2022 Jan 6 1
5 35163252 Emerging Connections between Nuclear Pore Complex Homeostasis and ALS. 2022 Jan 25 1
6 35164882 Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation. 2022 Feb 14 1
7 35269468 The Neurotoxicity of Vesicles Secreted by ALS Patient Myotubes Is Specific to Exosome-Like and Not Larger Subtypes. 2022 Mar 1 1
8 35325178 Optical control of protein delivery and partitioning in the nucleolus. 2022 Mar 23 1
9 35379698 Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis. 2022 Apr 4 2
10 35568435 C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons. 2022 Sep 1
11 35589706 Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. 2022 May 19 1
12 35589711 Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD. 2022 May 19 1
13 33433873 Fluid Biomarkers of Frontotemporal Lobar Degeneration. 2021 1
14 33495278 SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72. 2021 Feb 19 1
15 33551183 Open Access: A Role for p53 in c9ALS/FTD? 2021 May 1
16 33619157 Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis. 2021 Apr 1
17 33632058 C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels. 2021 Nov 1
18 33679328 Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD. 2021 2
19 33837088 C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility. 2021 Apr 1
20 33967699 Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD. 2021 1
21 34099711 Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis. 2021 Jun 7 1
22 34161229 Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model. 2021 Jun 23 1
23 34481908 NEAT1 lncRNA and amyotrophic lateral sclerosis. 2021 Nov 1
24 34499080 Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine. 2021 Nov 1 1
25 34551427 ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. 2021 Nov 8 1
26 34751579 Aggregation and the Intrinsic Structural Disorder of Dipeptide Repeat Peptides of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Characterized by NMR. 2021 Nov 18 2
27 34768862 p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR. 2021 Oct 22 1
28 34827542 Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD. 2021 Nov 20 1
29 34975412 Emerging Mechanisms Underpinning Neurophysiological Impairments in C9ORF72 Repeat Expansion-Mediated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. 2021 1
30 35096836 HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS. 2021 1
31 32027933 UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins. 2020 May 1
32 32086375 Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity. 2020 Apr 1
33 32093728 Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD. 2020 Feb 24 1
34 32100453 C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis. 2020 Apr 3
35 32119645 C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import. 2020 Mar 2 1
36 32266467 CRISPR deletion of the C9ORF72 promoter in ALS/FTD patient motor neurons abolishes production of dipeptide repeat proteins and rescues neurodegeneration. 2020 Jul 1
37 32347002 Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. 2020 May 8 1
38 32375063 Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36. 2020 Jul 22 1
39 32562018 Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. 2020 Aug 1
40 32620797 C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression. 2020 Jul 3 1
41 32730793 Phase Separation of Toxic Dipeptide Repeat Proteins Related to C9orf72 ALS/FTD. 2020 Aug 18 1
42 32814898 C9orf72 in myeloid cells suppresses STING-induced inflammation. 2020 Sep 2
43 32860626 Role of the C9ORF72 Gene in the Pathogenesis of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. 2020 Sep 1
44 32862270 Dipeptide repeat protein and TDP-43 pathology along the hypothalamic-pituitary axis in C9orf72 and non-C9orf72 ALS and FTLD-TDP cases. 2020 Nov 1
45 32958650 Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. 2020 Oct 6 1
46 33168090 Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity. 2020 Nov 9 1
47 30368547 C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies. 2019 Jan 1
48 30617154 Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. 2019 Feb 1
49 30639592 Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins. 2019 Apr 15 2
50 30774737 Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion. 2019 1