perfluorooctanoic acid

peroxisome proliferator activated receptor alpha ; Mus musculus







35 Article(s)
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1 34826932 Exposure of male mice to perfluorooctanoic acid induces anxiety-like behaviors by increasing corticotropin-releasing factor in the basolateral amygdala complex. 2022 Jan 4
2 32307816 Exposure of female mice to perfluorooctanoic acid suppresses hypothalamic kisspeptin-reproductive endocrine system through enhanced hepatic fibroblast growth factor 21 synthesis, leading to ovulation failure and prolonged dioestrus. 2020 May 2
3 32822737 Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet. 2020 Oct 15 3
4 30685356 Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid. 2019 Mar 15 6
5 30711707 The effects of perfluorooctanoate on high fat diet induced non-alcoholic fatty liver disease in mice. 2019 Mar 15 4
6 31062244 Maternal exposure to perfluorooctanoic acid (PFOA) causes liver toxicity through PPAR-α pathway and lowered histone acetylation in female offspring mice. 2019 Jun 3
7 28032147 Comparative hepatotoxicity of 6:2 fluorotelomer carboxylic acid and 6:2 fluorotelomer sulfonic acid, two fluorinated alternatives to long-chain perfluoroalkyl acids, on adult male mice. 2017 Aug 2
8 25594567 Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPARα and T- and B-cell targeting. 2016 2
9 25092180 Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days. 2015 Sep 7
10 25398757 Perfluorooctanoic Acid (PFOA)-induced Liver Lesions in Two Strains of Mice Following Developmental Exposures: PPARα Is Not Required. 2015 Jun 7
11 24374136 Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation. 2014 Feb 28 2
12 23143925 A species difference in the peroxisome proliferator-activated receptor α-dependent response to the developmental effects of perfluorooctanoic acid. 2013 Feb 1
13 23435180 Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid. 2013 Apr 5 1
14 21499893 Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice. 2012 Jan 6
15 22154759 Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. 2012 Jul 4
16 22414604 Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice. 2012 Jul 4
17 21712084 Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα. 2011 Sep 10 4
18 20118188 Perfluorooctanoic acid effects on steroid hormone and growth factor levels mediate stimulation of peripubertal mammary gland development in C57BL/6 mice. 2010 May 4
19 20160413 Role of peroxisome proliferator-activated receptor-alpha in hepatobiliary injury induced by ammonium perfluorooctanoate in mouse liver. 2010 5
20 20614104 Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. 2010 Oct 1
21 20637823 Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development. 2010 Sep 30 2
22 18595657 Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse. 2009 Jun 3
23 19162173 Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species. 2009 Jun 1
24 19429403 Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: comparison to changes induced by exposure to perfluorooctanoic acid. 2009 Jun 1
25 19751795 Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha. 2009 Nov 9 1
26 18281256 Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. 2008 May 3
27 18360689 The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha. 2008 Apr 1
28 18467677 Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid. 2008 Jun 4
29 18467680 Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice. 2008 Jun 1
30 18703564 Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. 2008 Nov 4
31 18757529 Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. 2008 Dec 3
32 17488742 Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha. 2007 Aug 3
33 17259670 Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlpha. 2006 1
34 12034374 Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice. 2002 May 15 1
35 10581215 trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. 1999 Dec 1 1