Clofibrate

peroxisome proliferator activated receptor alpha ; Mus musculus







42 Article(s)
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1 32070771 Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. 2020 Jun 1 1
2 29175453 Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. 2018 Jan 1 1
3 28973556 Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner. 2017 Dec 1 1
4 29095960 Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood. 2017 2
5 26850476 Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses. 2016 Apr 3
6 25896250 Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. 2015 Jul 1
7 26465636 In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier. 2015 Dec 4
8 25383754 Icariin is a PPARα activator inducing lipid metabolic gene expression in mice. 2014 Nov 6 1
9 22037025 PPARα is down-regulated following liver transplantation in mice. 2012 Mar 1
10 21338618 Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration. 2011 May 1 4
11 21846997 Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery. 2011 2
12 20637823 Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development. 2010 Sep 30 1
13 19336949 Regulation of adiponectin receptor 2 expression via PPAR-alpha in NIT-1 cells. 2009 4
14 19533851 The role of endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the regulation of inflammation in macrophages. 2009 Jul 2
15 17984196 Peroxisome proliferator-activated receptor-alpha contributes to the anti-inflammatory activity of glucocorticoids. 2008 Feb 1
16 18188449 PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. 2008 Feb 1
17 18501395 Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. 2008 Aug 1 2
18 18596730 Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension. 2008 Oct 3
19 18723825 Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. 2008 Dec 1
20 19107217 Regulation of peroxisome proliferator-activated receptors by e6-associated protein. 2008 3
21 17962186 Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. 2007 Dec 14 1
22 16467456 Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. 2006 May 2
23 16600694 Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells. 2006 Jun 1
24 15367102 Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. 2005 Jan 15 1
25 16054168 NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)alpha-mediated cardiovascular effects. 2005 Nov 11 1
26 16135818 Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. 2005 Sep 3
27 16257849 Evaluation of the carcinogenic potential of clofibrate in the p53+/- mouse. 2005 Sep-Oct 2
28 16257851 Evaluation of the carcinogenic potential of clofibrate in the FVB/Tg.AC mouse after oral administration--part I. 2005 Sep-Oct 2
29 16257853 Evaluation of the carcinogenic potential of clofibrate in the neonatal mouse. 2005 Sep-Oct 1
30 12680773 Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate. 2003 Apr 15 3
31 11160642 Molecular cloning and regulation of expression of two novel mouse CYP4F genes: expression in peroxisome proliferator-activated receptor alpha-deficient mice upon lipopolysaccharide and clofibrate challenges. 2001 Feb 1
32 11171094 Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. 2001 Feb 15 2
33 10753628 Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro. 2000 Apr 13 1
34 10787442 Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases. 2000 May 1
35 10951269 Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis. 2000 Sep 1
36 11006348 PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate. 2000 Oct 2
37 11006363 Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure. 2000 Oct 2
38 10454501 Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. 1999 Sep 1
39 8557642 Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2. 1996 Jan 12 2
40 8700121 Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. 1996 Jul 1
41 8993548 Peroxisome proliferator-activated receptors: structures and function. 1996 Dec 27 3
42 8127882 Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. 1994 Mar 1 1