cucurbitacin I

signal transducer and activator of transcription 3 ; Mus musculus







22 Article(s)
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1 35517401 Cucurbitacin I inhibits the proliferation of pancreatic cancer through the JAK2/STAT3 signalling pathway in vivo and in vitro. 2022 3
2 31469186 CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice. 2020 Apr 1
3 30916811 STAT3 signalling pathway is implicated in keloid pathogenesis by preliminary transcriptome and open chromatin analyses. 2019 Apr 2
4 30083161 SOCS3 Suppression Promoted the Recruitment of CD11b+Gr-1-F4/80-MHCII- Early-Stage Myeloid-Derived Suppressor Cells and Accelerated Interleukin-6-Related Tumor Invasion via Affecting Myeloid Differentiation in Breast Cancer. 2018 2
5 28221800 Self-Associating Poly(ethylene oxide)-block-poly(α-carboxyl-ε-caprolactone) Drug Conjugates for the Delivery of STAT3 Inhibitor JSI-124: Potential Application in Cancer Immunotherapy. 2017 Aug 7 2
6 27203698 Myeloid-derived suppressor cells are essential for maintaining feto-maternal immunotolerance via STAT3 signaling in mice. 2016 Sep 1
7 26255115 Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-α. 2015 Oct 3
8 24316209 Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling. 2014 Feb 2
9 25013518 JSI124 inhibits breast cancer cell growth by suppressing the function of B cells via the downregulation of signal transducer and activator of transcription 3. 2014 Aug 5
10 25139620 Downregulation of endogenous STAT3 augments tumoricidal activity of interleukin 15 activated dendritic cell against lymphoma and leukemia via TRAIL. 2014 Oct 1 2
11 23374901 Hypothermia enhances induction of protective protein metallothionein under ischemia. 2013 Feb 4 1
12 23897117 Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway. 2013 Nov 1
13 22249380 Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells. 2012 Mar 2
14 22328572 Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. 2012 May 4
15 22581828 Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. 2012 Aug 1
16 23166651 Murine myeloid dendritic cells that phagocytose apoptotic T cells inhibit the immune response via NO. 2012 1
17 20030320 Development of a poly(d,l-lactic-co-glycolic acid) nanoparticle formulation of STAT3 inhibitor JSI-124: implication for cancer immunotherapy. 2010 Apr 5 2
18 20124472 The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo. 2010 Feb 15 2
19 18798092 Immunomodulatory and anticancer effects of intra-tumoral co-delivery of synthetic lipid A adjuvant and STAT3 inhibitor, JSI-124. 2009 Jun 2
20 19471105 STAT3 mediates protection from liver inflammation after partial hepatectomy. 2009 1
21 18392040 Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model. 2008 Aug-Sep 2
22 12649187 Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. 2003 Mar 15 1