2-mercaptopyrazine

nudix hydrolase 15 ; Homo sapiens







90 Article(s)
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1 32842934 A rare case of Azathioprine-induced leukopenia in an European woman. 2022 Feb 2
2 33472343 Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosity. 2022 Jan 1
3 34412101 Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia. 2022 Feb 1 3
4 34866237 Effect of NUDT15 polymorphisms on early hematological safety of low-dose azathioprine in Chinese patients with pemphigus vulgaris: A prospective cohort study. 2022 Apr 2
5 35067667 Inosine Triphosphate Pyrophosphatase and NUDT15 are Good Predictors of Clinical Outcomes in Thiopurine-Treated Chinese Patients with Inflammatory Bowel Disease. 2022 Jun 1 2
6 35118815 Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity. 2022 Apr 1
7 35289057 Nudix hydrolase 15 loss-of-function variants in an Australian inflammatory bowel disease population. 2022 Mar 14 1
8 35468862 A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population. 2022 Apr 25 4
9 35498806 NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities. 2022 2
10 33063676 Quantification of Thioguanine in DNA Using Liquid Chromatography-Tandem Mass Spectrometry for Routine Thiopurine Drug Monitoring in Patients With Pediatric Acute Lymphoblastic Leukemia. 2021 Mar 1 1
11 33625081 Association of Multiple Gene Polymorphisms Including Homozygous NUDT15 R139C With Thiopurine Intolerance During the Treatment of Acute Lymphoblastic Leukemia. 2021 Nov 1 2
12 33675810 NUDT15: A bench to bedside success story. 2021 Jun 5
13 33753169 Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. 2021 Jan-Jun 5
14 33939894 Fatal thiopurine toxicity: pre-emptive testing of NUDT15 415C>T polymorphism may be life saving in South Asian population. 2021 May 3 1
15 33958640 Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT. 2021 May 6 2
16 34192970 A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T. 2021 Sep 2
17 34219339 NUDT15: A major determinant of thiopurine sensitivity in Asians. 2021 Jul 1
18 34234136 NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir. 2021 Jul 7 1
19 34287682 Thiopurine pharmacogenomics and pregnancy in inflammatory bowel disease. 2021 Oct 1
20 34425754 TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India. 2021 Aug 23 4
21 34442422 Importance of NUDT15 Polymorphisms in Thiopurine Treatments. 2021 Aug 10 3
22 34480209 Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation. 2021 Nov 4
23 34563096 Randomised clinical trial: dose optimising strategy by NUDT15 genotyping reduces leucopenia during thiopurine treatment of Crohn's disease. 2021 Nov 2
24 34636169 NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells. 2021 Nov 1
25 34720526 Biomarkers for gastrointestinal adverse events related to thiopurine therapy. 2021 Oct 14 1
26 34925040 Meta-Analysis of NUDT15 Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations. 2021 6
27 31651720 Pharmacogeomic implications of population diversity in Latin America: TPMT and NUDT15 polymorphisms and thiopurine dosing. 2020 Jan 1
28 32094176 Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity. 2020 Mar 10 4
29 32124692 Clinical Application of Thiopurine Pharmacogenomics in Pediatrics. 2020 1
30 32269192 Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis. 2020 Jul 1 1
31 32294118 Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil. 2020 2
32 32308129 NUDT15 genetic variants are related to thiopurine-induced neutropenia in Thai children with acute lymphoblastic leukemia. 2020 Apr 2
33 32438538 Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn's disease who turned out to possess homozygous mutations in NUDT15 R139C. 2020 Oct 2
34 32453263 Pharmacogenomics of thiopurines: distribution of TPMT and NUDT15 polymorphisms in the Brazilian Amazon. 2020 Oct 1
35 32598049 Adjustment of azathioprine dose should be based on a lower 6-TGN target level to avoid leucopenia in NUDT15 intermediate metabolisers. 2020 Aug 2
36 32611418 Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT. 2020 Jul 1 3
37 32690945 Development of a chemical probe against NUDT15. 2020 Oct 2
38 33111378 NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India. 2020 Dec 1
39 33256902 Pharmacogenomics and ALL treatment: How to optimize therapy. 2020 Jul 1
40 33584261 Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases. 2020 1
41 30447069 Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update. 2019 May 1
42 30639426 Thiopurine intolerance-causing mutations in NUDT15 induce temperature-dependent destabilization of the catalytic site. 2019 Apr 2
43 30728528 Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry. 2019 Sep 4
44 30806694 Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease. 2019 Feb 26 3
45 30909691 The Nudix Hydrolase 15 (NUDT15) Gene Variants among Jordanian Arab Population 2019 Mar 26 4
46 30945335 Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tango. 2019 Jul 1
47 31024313 NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis. 2019 2
48 31045285 Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine. 2019 Oct 5
49 31210708 Predicting (side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics. 2019 Jun 7 2
50 31244663 Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients. 2019 1