Protein Name enolase 1
Organism Homo sapiens
Gene ID 2023
Gene Symbol

ENO1

UniProt P06733 (ENOA_HUMAN), A0A024R4F1 (A0A024R4F1_HUMAN)
Relationships Total Number of functionally related compound(s) : 424
Total Number of Articles : 302
Description

enolase 1

Gene Summary

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

synonyms
  • alpha-enolase
  • c-myc promoter-binding protein-1
  • 2-phospho-D-glycerate hydro-lyase
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Properties