Protein Name grainyhead like transcription factor 2
Organism Mus musculus
Gene ID 252973
Gene Symbol

Grhl2

UniProt Q8K5C0 (GRHL2_MOUSE), Q9DCN4 (Q9DCN4_MOUSE)
Relationships Total Number of functionally related compound(s) : 17
Total Number of Articles : 10
Description

grainyhead like transcription factor 2

Gene Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epithelial cell differentiation; neural tube closure; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and face development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • grainyhead-like protein 2 homolog
  • brother of mammalian grainyhead
  • grainyhead like 2
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Properties