Protein Name alpha-2-macroglobulin
Organism Rattus norvegicus
Gene ID 24153
Gene Symbol

A2m

UniProt P06238 (A2MG_RAT)
Relationships Total Number of functionally related compound(s) : 188
Total Number of Articles : 199
Description

alpha-2-macroglobulin

Gene Summary

Enables endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and luteinization. Located in extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • alpha-2-macroglobulin
  • alpha-2-M
  • alpha-2-macroglobulin-P
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Properties