Protein Name protein tyrosine phosphatase receptor type F
Organism Homo sapiens
Gene ID 5792
Gene Symbol

PTPRF

UniProt P10586 (PTPRF_HUMAN), G1UI20 (G1UI20_HUMAN)
Relationships Total Number of functionally related compound(s) : 114
Total Number of Articles : 222
Description

protein tyrosine phosphatase receptor type F

Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

synonyms
  • receptor-type tyrosine-protein phosphatase F
  • LCA-homolog
  • leukocyte antigen-related (LAR) PTP receptor
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Properties