Protein Name HLF transcription factor, PAR bZIP family member
Organism Homo sapiens
Gene ID 3131
Gene Symbol

HLF

UniProt Q16534 (HLF_HUMAN)
Relationships Total Number of functionally related compound(s) : 187
Total Number of Articles : 173
Description

HLF transcription factor, PAR bZIP family member

Gene Summary

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

synonyms
  • hepatic leukemia factor
  • E2A-HLF fusion transcript protein
  • HLF, PAR bZIP transcription factor
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Properties