Protein Name Fc receptor, IgG, low affinity IIb
Organism Mus musculus
Gene ID 14130
Gene Symbol

Fcgr2b

UniProt P08101 (FCGR2_MOUSE), A0A0B4J1E6 (A0A0B4J1E6_MOUSE), A0A0B4J1G1 (A0A0B4J1G1_MOUSE)
Relationships Total Number of functionally related compound(s) : 115
Total Number of Articles : 123
Description

Fc receptor, IgG, low affinity IIb

Gene Summary

Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; nervous system development; and regulation of cellular response to stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is integral component of membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • low affinity immunoglobulin gamma Fc region receptor II-b
  • Fc gamma RIIB
  • Fc-gamma-RII
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Properties