Protein Name | chaperonin containing TCP1 subunit 4 |
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Organism | Homo sapiens |
Gene ID | 10575 |
Gene Symbol | CCT4 |
UniProt | P50991 (TCPD_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
264
Total Number of Articles : 257 |
Description |
chaperonin containing TCP1 subunit 4 |
Gene Summary |
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008] |
synonyms |
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Properties | |