Protein Name ribosomal protein S6
Organism Homo sapiens
Gene ID 6194
Gene Symbol


UniProt P62753 (RS6_HUMAN), A2A3R6 (A2A3R6_HUMAN)
Relationships Total Number of functionally related compound(s) : 149
Total Number of Articles : 179

ribosomal protein S6

Gene Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

  • small ribosomal subunit protein eS6
  • 40S ribosomal protein S6
  • phosphoprotein NP33
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