Protein Name POU domain, class 3, transcription factor 4
Organism Mus musculus
Gene ID 18994
Gene Symbol

Pou3f4

UniProt P62515 (PO3F4_MOUSE), A6H6L6 (A6H6L6_MOUSE)
Relationships Total Number of functionally related compound(s) : 8
Total Number of Articles : 5
Description

POU domain, class 3, transcription factor 4

Gene Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cochlea morphogenesis and negative regulation of mesenchymal cell apoptotic process. Acts upstream of or within forebrain neuron differentiation; inner ear development; and sensory perception of sound. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; cranium; ear; embryo ectoderm; and foregut-midgut junction. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to human POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • POU domain, class 3, transcription factor 4
  • brain-4 class III POU-domain protein
  • brain-specific homeobox/POU domain protein 4
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Properties