Protein Name C-C motif chemokine ligand 2
Organism Rattus norvegicus
Gene ID 24770
Gene Symbol

Ccl2

UniProt P14844 (CCL2_RAT)
Relationships Total Number of functionally related compound(s) : 625
Total Number of Articles : 829
Description

C-C motif chemokine ligand 2

Gene Summary

Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte migration. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Colocalizes with C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • C-C motif chemokine 2
  • chemokine (C-C motif) ligand 2
  • immediate-early serum-responsive JE protein
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Properties