| Protein Name | platelet factor 4 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 360918 |
| Gene Symbol | Pf4 |
| UniProt | P06765 (PLF4_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
30
Total Number of Articles : 31 |
Description |
platelet factor 4 |
| Gene Summary |
Predicted to enable CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in several processes, including negative regulation of T-helper 17 cell differentiation; negative regulation of inflammatory response; and response to aldosterone. Located in platelet alpha granule. Part of protein-containing complex. Biomarker of acute myocardial infarction; anti-basement membrane glomerulonephritis; diabetic retinopathy; and retinal degeneration. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to several human genes including PF4 (platelet factor 4). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |