Protein Name Raf-1 proto-oncogene, serine/threonine kinase
Organism Rattus norvegicus
Gene ID 24703
Gene Symbol

Raf1

UniProt P11345 (RAF1_RAT)
Relationships Total Number of functionally related compound(s) : 170
Total Number of Articles : 186
Description

Raf-1 proto-oncogene, serine/threonine kinase

Gene Summary

Enables several functions, including ATP binding activity; adenylate cyclase activator activity; and enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • RAF proto-oncogene serine/threonine-protein kinase
  • C-RAF
  • cRaf
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Properties