Protein Name fibroblast growth factor receptor 4
Organism Homo sapiens
Gene ID 2264
Gene Symbol

FGFR4

UniProt P22455 (FGFR4_HUMAN), J3KPQ0 (J3KPQ0_HUMAN), B4DVP5 (B4DVP5_HUMAN)
Relationships Total Number of functionally related compound(s) : 174
Total Number of Articles : 190
Description

fibroblast growth factor receptor 4

Gene Summary

The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]

synonyms
  • fibroblast growth factor receptor 4
  • hydroxyaryl-protein kinase
  • protein-tyrosine kinase
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Properties