Protein Name neutrophil cytosolic factor 2
Organism Homo sapiens
Gene ID 4688
Gene Symbol


UniProt P19878 (NCF2_HUMAN), A0A0S2Z457 (A0A0S2Z457_HUMAN)
Relationships Total Number of functionally related compound(s) : 110
Total Number of Articles : 163

neutrophil cytosolic factor 2

Gene Summary

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

  • neutrophil cytosol factor 2
  • 67 kDa neutrophil oxidase factor
  • NADPH oxidase activator 2
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