Protein Name solute carrier family 18 member A2
Organism Rattus norvegicus
Gene ID 25549
Gene Symbol

Slc18a2

UniProt Q01827 (VMAT2_RAT), A0A0G2JSJ6 (A0A0G2JSJ6_RAT)
Relationships Total Number of functionally related compound(s) : 176
Total Number of Articles : 187
Description

solute carrier family 18 member A2

Gene Summary

Enables several functions, including amine transmembrane transporter activity; enzyme binding activity; and heat shock protein binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; response to herbicide; and serotonin uptake. Located in neuronal cell body; secretory vesicle; and terminal bouton. Is active in dopaminergic synapse; neuronal dense core vesicle; and postsynapse. Is integral component of neuronal dense core vesicle membrane and integral component of synaptic vesicle membrane. Used to study Parkinson's disease and type 1 diabetes mellitus. Biomarker of Machado-Joseph disease; Parkinson's disease; substance-related disorder; and toxic encephalopathy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • synaptic vesicular amine transporter
  • Solute carrier family 18 A2 (vesicular monoamine transporter 2)
  • VAT2
Click to show/hide the synonyms
Properties