Protein Name solute carrier family 18 member A2
Organism Rattus norvegicus
Gene ID 25549
Gene Symbol

Slc18a2

UniProt Q01827 (VMAT2_RAT), A0A0G2JSJ6 (A0A0G2JSJ6_RAT)
Relationships Total Number of functionally related compound(s) : 176
Total Number of Articles : 187
Description

solute carrier family 18 member A2

Gene Summary

Enables several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and monoamine:proton antiporter activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; neurotransmitter uptake; and signal release. Located in several cellular components, including neuronal cell body; secretory vesicle; and terminal bouton. Is active in dopaminergic synapse; postsynapse; and secretory vesicle. Used to study Parkinson's disease and type 1 diabetes mellitus. Biomarker of Machado-Joseph disease; Parkinson's disease; substance-related disorder; and toxic encephalopathy. Human ortholog(s) of this gene implicated in Parkinson's disease and infantile parkinsonism-dystonia 2. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • synaptic vesicular amine transporter
  • Solute carrier family 18 A2 (vesicular monoamine transporter 2)
  • VAT2
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Properties