Protein Name nucleotide-binding oligomerization domain containing 2
Organism Danio rerio
Gene ID 777696
Gene Symbol

nod2

UniProt F8W3K2 (F8W3K2_DANRE)
Relationships Total Number of functionally related compound(s) : 8
Total Number of Articles : 3
Description

nucleotide-binding oligomerization domain containing 2

Gene Summary

Predicted to enable CARD domain binding activity. Acts upstream of with a positive effect on regulation of canonical NF-kappaB signal transduction and regulation of gene expression. Acts upstream of or within defense response to bacterium; defense response to virus; and regulation of DNA-templated transcription. Located in cytoplasm. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • nucleotide-binding oligomerization domain-containing protein 2
  • NLR-A2
  • NOD2a protein
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Properties