Protein Name leptin receptor
Organism Homo sapiens
Gene ID 3953
Gene Symbol


UniProt P48357 (LEPR_HUMAN), Q4G138 (Q4G138_HUMAN)
Relationships Total Number of functionally related compound(s) : 190
Total Number of Articles : 206

leptin receptor

Gene Summary

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

  • leptin receptor
  • OB receptor
  • huB219
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