Protein Name proteolipid protein 1
Organism Homo sapiens
Gene ID 5354
Gene Symbol

PLP1

UniProt P60201 (MYPR_HUMAN), A8K9L3 (A8K9L3_HUMAN), A0A0S2Z4D4 (A0A0S2Z4D4_HUMAN), B4DI30 (B4DI30_HUMAN)
Relationships Total Number of functionally related compound(s) : 386
Total Number of Articles : 302
Description

proteolipid protein 1

Gene Summary

This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]

synonyms
  • myelin proteolipid protein
  • lipophilin
  • major myelin proteolipid protein
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Properties