Protein Name thyroglobulin
Organism Homo sapiens
Gene ID 7038
Gene Symbol

TG

UniProt P01266 (THYG_HUMAN)
Relationships Total Number of functionally related compound(s) : 343
Total Number of Articles : 913
Description

thyroglobulin

Gene Summary

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

synonyms
  • thyroglobulin
  • AITD3
  • TGN
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Properties