Protein Name fucosyltransferase 3 (Lewis blood group)
Organism Homo sapiens
Gene ID 2525
Gene Symbol

FUT3

UniProt P21217 (FUT3_HUMAN), A8K737 (A8K737_HUMAN)
Relationships Total Number of functionally related compound(s) : 80
Total Number of Articles : 80
Description

fucosyltransferase 3 (Lewis blood group)

Gene Summary

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]

synonyms
  • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
  • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3
  • 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
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Properties