Protein Name hepatocyte nuclear factor 4 alpha
Organism Homo sapiens
Gene ID 3172
Gene Symbol

HNF4A

UniProt P41235 (HNF4A_HUMAN), F1D8T0 (F1D8T0_HUMAN), B9VVT8 (B9VVT8_HUMAN), F1D8T1 (F1D8T1_HUMAN), F1D8S2 (F1D8S2_HUMAN), A0A087WXV4 (A0A087WXV4_HUMAN)
Relationships Total Number of functionally related compound(s) : 524
Total Number of Articles : 735
Description

hepatocyte nuclear factor 4 alpha

Gene Summary

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

synonyms
  • hepatocyte nuclear factor 4-alpha
  • HNF4A wild type
  • HNF4alpha10/11/12
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Properties