Protein Name ATP binding cassette subfamily B member 4
Organism Homo sapiens
Gene ID 5244
Gene Symbol

ABCB4

UniProt P21439 (MDR3_HUMAN)
Relationships Total Number of functionally related compound(s) : 175
Total Number of Articles : 246
Description

ATP binding cassette subfamily B member 4

Gene Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

synonyms
  • phosphatidylcholine translocator ABCB4
  • ATP-binding cassette sub-family B member 4
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4
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Properties