Protein Name guanine monophosphate synthase
Organism Homo sapiens
Gene ID 8833
Gene Symbol

GMPS

UniProt P49915 (GUAA_HUMAN), A0A140VJK6 (A0A140VJK6_HUMAN)
Relationships Total Number of functionally related compound(s) : 53
Total Number of Articles : 38
Description

guanine monophosphate synthase

Gene Summary

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

synonyms
  • GMP synthase [glutamine-hydrolyzing]
  • GMP synthase
  • GMP synthetase
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Properties