Protein Name anti-Mullerian hormone
Organism Homo sapiens
Gene ID 268
Gene Symbol


UniProt P03971 (MIS_HUMAN)
Relationships Total Number of functionally related compound(s) : 401
Total Number of Articles : 666

anti-Mullerian hormone

Gene Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]

  • muellerian-inhibiting factor
  • Mullerian inhibiting factor
  • Mullerian inhibiting substance
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