| Protein Name | apolipoprotein C1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 341 |
| Gene Symbol | APOC1 |
| UniProt | P02654 (APOC1_HUMAN), A0A024R0T8 (A0A024R0T8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
89
Total Number of Articles : 113 |
Description |
apolipoprotein C1 |
| Gene Summary |
This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016] |
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