Protein Name glutamic--pyruvic transaminase
Organism Homo sapiens
Gene ID 2875
Gene Symbol

GPT

UniProt P24298 (ALAT1_HUMAN)
Relationships Total Number of functionally related compound(s) : 774
Total Number of Articles : 1163
Description

glutamic--pyruvic transaminase

Gene Summary

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

synonyms
  • alanine aminotransferase 1
  • alanine aminotransferase
  • alanine transaminase
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Properties