Protein Name filaggrin
Organism Homo sapiens
Gene ID 2312
Gene Symbol


UniProt P20930 (FILA_HUMAN)
Relationships Total Number of functionally related compound(s) : 201
Total Number of Articles : 204


Gene Summary

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

  • filaggrin
  • epidermal filaggrin
  • ATOD2
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