Protein Name down-regulator of transcription 1
Organism Homo sapiens
Gene ID 1810
Gene Symbol

DR1

UniProt Q01658 (NC2B_HUMAN), Q658N3 (Q658N3_HUMAN)
Relationships Total Number of functionally related compound(s) : 138
Total Number of Articles : 142
Description

down-regulator of transcription 1

Gene Summary

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

synonyms
  • protein Dr1
  • TATA-binding protein-associated phosphoprotein
  • negative cofactor 2
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Properties