Protein Name prostaglandin E receptor 1
Organism Homo sapiens
Gene ID 5731
Gene Symbol


UniProt P34995 (PE2R1_HUMAN)
Relationships Total Number of functionally related compound(s) : 188
Total Number of Articles : 341

prostaglandin E receptor 1

Gene Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]

  • prostaglandin E2 receptor EP1 subtype
  • PGE receptor, EP1 subtype
  • PGE2 receptor EP1 subtype
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