| Protein Name | interleukin 13 receptor, alpha 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16165 |
| Gene Symbol | Il13ra2 |
| UniProt | O88786 (I13R2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
14
Total Number of Articles : 16 |
Description |
interleukin 13 receptor, alpha 2 |
| Gene Summary |
This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
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